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107585 Ensembl ENSG00000197406 ENSMUSG00000075707 UniProt P55073 Q91ZI8 RefSeq (mRNA) NM_001362 NM_172119 RefSeq (protein) NP_001353 NP_742117 Location (UCSC) Chr 14: 101.56 – 101.56 Mb Chr 12: 110.25 – 110.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thyroxine 5-deiodinase also known as type III iodothyronine deiodinase (EC number 1.21.99.3) is an enzyme that in humans is ...
Iodothyronine deiodinases (EC 1.21.99.4 and EC 1.21.99.3) are a subfamily of deiodinase enzymes important in the activation and deactivation of thyroid hormones. Thyroxine (T 4), the precursor of 3,5,3'-triiodothyronine (T 3) is transformed into T 3 by deiodinase activity.
Three related isoforms, deiodinase type I, II, and III, contribute to activation and inactivation of the initially released hormone precursor T 4 into T 3 (triiodothyronine) or rT 3 (reverse triiodothyronine) in target cells. The enzymes catalyze a reductive elimination of iodine (the different isoforms attack different thyronine positions ...
This receptor-corepressor-DNA complex can block gene transcription. Triiodothyronine (T 3), which is the active form of thyroxine (T 4), goes on to bind to receptors. The deiodinase catalyzed reaction removes an iodine atom from the 5′ position of the outer aromatic ring of thyroxine's (T 4) structure. [64]
This list may not reflect recent changes. B. ... Thyroxine 5-deiodinase This page was last edited on 5 September 2015, at 07:42 (UTC). Text is available under the ...
Reverse triiodothyronine, also known as rT 3, is an isomer of triiodothyronine (T 3).. Reverse T 3 is the third-most common iodothyronine the thyroid gland releases into the bloodstream, at 0.9%; tetraiodothyronine (levothyroxine, T 4) constitutes 90% and T 3 is 9%.
Category:EC 1.5.5 (with a quinone or similar compound as acceptor) Category:EC 1.5.7 (with an iron–sulfur protein as acceptor) Category:EC 1.5.8 (with a flavin as acceptor)
Thyroxine deiodinase may refer to: Iodothyronine deiodinase; Thyroxine 5-deiodinase This page was last edited on 20 October 2024, at 09:40 (UTC). Text is available ...