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107585 Ensembl ENSG00000197406 ENSMUSG00000075707 UniProt P55073 Q91ZI8 RefSeq (mRNA) NM_001362 NM_172119 RefSeq (protein) NP_001353 NP_742117 Location (UCSC) Chr 14: 101.56 – 101.56 Mb Chr 12: 110.25 – 110.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thyroxine 5-deiodinase also known as type III iodothyronine deiodinase (EC number 1.21.99.3) is an enzyme that in humans is ...
Iodothyronine deiodinases (EC 1.21.99.4 and EC 1.21.99.3) are a subfamily of deiodinase enzymes important in the activation and deactivation of thyroid hormones. Thyroxine (T 4), the precursor of 3,5,3'-triiodothyronine (T 3) is transformed into T 3 by deiodinase activity.
This receptor-corepressor-DNA complex can block gene transcription. Triiodothyronine (T 3), which is the active form of thyroxine (T 4), goes on to bind to receptors. The deiodinase catalyzed reaction removes an iodine atom from the 5′ position of the outer aromatic ring of thyroxine's (T 4) structure. [64]
Three related isoforms, deiodinase type I, II, and III, contribute to activation and inactivation of the initially released hormone precursor T 4 into T 3 (triiodothyronine) or rT 3 (reverse triiodothyronine) in target cells. The enzymes catalyze a reductive elimination of iodine (the different isoforms attack different thyronine positions ...
This list may not reflect recent changes. B. ... Thyroxine 5-deiodinase This page was last edited on 5 September 2015, at 07:42 (UTC). Text is available under the ...
Thyroxine deiodinase may refer to: Iodothyronine deiodinase; Thyroxine 5-deiodinase This page was last edited on 20 October 2024, at 09:40 (UTC). Text is available ...
3,5-T 2 is an active thyroid hormone. It stimulates the TR-beta receptor for thyroid hormones and thus increases energy expenditure . [ 1 ] [ 2 ] It has agonistic (thyromimetic) effects at myocardial tissue and pituitary , which results in 3,5-T 2 suppressing TSH release.
The following is a list of hormones found in Humans. Spelling is not uniform for many hormones. Spelling is not uniform for many hormones. For example, current North American and international usage uses [ citation needed ] estrogen and gonadotropin, while British usage retains the Greek digraph in oestrogen and favours the earlier spelling ...