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Levofloxacin was patented in 1985 and approved for medical use in the United States in 1996. [7] [10] It is on the World Health Organization's List of Essential Medicines. [11] It is available as a generic medication. [7] In 2022, it was the 251st most commonly prescribed medication in the United States, with more than 1 million prescriptions ...
Dexamethasone/levofloxacin, sold under the brand name Levodexa, is a fixed-dose combination medication used for the prevention and treatment of inflammation, and the ...
PPI (standard dose) bid, bismuth standard dose qid and two antibiotics selected by sensitivity tests Third line therapy if there is no fluoroquinolone resistance Levofloxacin-based quadruple therapy 10 PPI (standard dose) bid, bismuth standard dose qid, levofloxacin 0.5 g qd and amoxicillin 1 g bid Third line therapy High-dose dual PPI therapy 14
Ofloxacin has not been shown to have any teratogenic effects at oral doses as high as 810 mg/kg/day (11 times the recommended maximum human dose based on mg/m 2 or 50 times based on mg/kg) and 160 mg/kg/day (four times the recommended maximum human dose based on mg/m 2 or 10 times based on mg/kg) when administered to pregnant rats and rabbits ...
The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). [6] It is also sometimes abbreviated as the ED 50, meaning "effective dose for 50% of the population". The ED50 is commonly used as a measure of the reasonable expectancy of ...
The IC 50 of a drug can be determined by constructing a dose-response curve and examining the effect of different concentrations of antagonist on reversing agonist activity. IC 50 values can be calculated for a given antagonist by determining the concentration needed to inhibit half of the maximum biological response of the agonist. [4]
The dose schedule given every two weeks is as follows: [5] Day 1–2: Oxaliplatin 100 mg/m 2 IV infusion, given as a 120 minutes IV infusion in 500 mL D5W, concurrent with leucovorin 400 mg/m 2 (or levoleucovorin 200 mg/m 2) IV infusion, followed by 5-FU 400 mg/m 2 IV bolus, followed by 46-hour 5-FU infusion (2400 mg/m 2 for first two cycles, and may be increased to 3000 mg/m 2 if tolerated by ...
The time that it takes for serum concentrations of clinafloxacin to reach the maximum concentration in healthy volunteers after taking a dose by mouth is 0.7 hours. [3] The elimination half-life in humans is 6.1 hours. [3] Steady state levels of clinafloxacin are achieved in 3 days of twice daily dosing by mouth in healthy volunteers. [1]
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