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The skin eruptions are often pruritic and accompanied by fever, headache, a high number of neutrophils and eosinophils in the blood, and elevated blood levels of markers for inflammation (i.e. erythrocyte sedimentation rate and C-reactive protein). The skin eruptions typically end within a week after causative drug is discontinued.
Papule: A papule is a circumscribed, solid elevation of skin, varying in size from less than either 5 [10] or 10 mm in diameter at the widest point. [ 30 ] Plaque : A plaque has been described as a broad papule, or confluence of papules equal to or greater than 10 mm, [ 30 ] or alternatively as an elevated, plateau-like lesion that is greater ...
A papule can be flesh colored, yellow, white, brown, black, blue or purplish, or varying shades of red. [4] [6] The intensity of redness might indicate how long the papule has been present. [6] There may be just one or many, and they may occur irregularly in different parts of the body or appear in clusters. [2] It may progress to a pustule or ...
There are numerous causes of palpable purpura, such as autoimmune diseases, drug reactions, vaccinations, and infections.The most common infectious causes are N. gonorrhoeae, S. aureus, and N. meningitides, however palpable purpura has also been caused by Mycoplasma spp., Rickettsiae, Mycobacterium, and very rarely by Treponema pallidum, Brucella spp., Yersinia, Campylobacter, and Bartonella.
Therefore, creatinine concentrations in blood and urine may be used to calculate the creatinine clearance (CrCl), which correlates approximately with the glomerular filtration rate (GFR). Blood creatinine concentrations may also be used alone to calculate the estimated GFR (eGFR). The GFR is clinically important as a measurement of kidney function.
One of the measures of kidney function is the glomerular filtration rate (GFR). Other tests that can assess the function of the kidneys include assessment of electrolyte levels such as potassium and phosphate, assessment of acid-base status by the measurement of bicarbonate levels from a vein, and assessment of the full blood count for anaemia.
Perioral dermatitis is frequently histologically similar to rosacea with the two conditions overlapping considerably. There is a lymphohistiocytic infiltrate with perifollicular localization and marked granulomatous inflammation. Occasionally, perifollicular abscesses may be present when pustules and papules are the dominant clinical findings. [7]
The papules and plaques often first appear within stretch marks before changing appearance and spreading to other areas of the body. For those who may be experiencing signs and symptoms of PUPPP, it is strongly recommended they speak with their primary care physician and receive a consult from a dermatologist regarding skin changes during ...