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Loop diuretics usually have a ceiling effect whereby doses greater than a certain maximum amount will not increase the clinical effect of the drug. Also, there is a threshold minimum concentration of loop diuretics that needs to be achieved at the thick ascending limb to enable the onset of abrupt diuresis. [10]
[1] Sometimes drugs cannot be compared across a wide range of treatment situations because one drug has a ceiling effect. [citation needed] Sometimes the desired effect increases with dose, but side-effects worsen or start being dangerous, and risk to benefit ratio increases. This is because of occupation of all the receptors in a given specimen.
GLP-1 drugs used for weight loss involve all kinds of side effects—good and not-so-good—that may or may not strike the average user. (Reminder that there are many of these meds now.
Canvassing all of the health effects of a new drug category like GLP-1s could be a novel way for agencies like the FDA to get an early understanding of a new medication’s potential benefits and ...
Other serious side effects may include hearing loss and low blood platelets. [2] Blood tests are recommended regularly for those on treatment. [2] Safety during pregnancy and breastfeeding is unclear. [3] Bumetanide is a loop diuretic and works by decreasing the reabsorption of sodium by the kidneys. [4] [2]
Some of the experimental drugs may go beyond diabetes and weight loss, improving liver and heart function while reducing side effects such as muscle loss common to the existing medications. At the ...