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Trade names for colchicine are Colcrys or Mitigare, which are manufactured as a dark– and light-blue capsule having a dose of 0.6 mg. [26] [76] Colchicine is also prepared as a white, yellow, or purple pill having a dose of 0.6 mg. [76] Colchicine is typically prescribed to mitigate or prevent the onset of gout, or its continuing symptoms and ...
In his work as a clinical trialist, Tardif has designed, conducted, and served as Principal Investigator for trials like COLCOT, [4] Dal-Gene, [5] INITIATIVE and SPIRE. [6] His work contributed to the approval of low-dose colchicine by Health Canada for the prevention of atherothrombotic events in patients with coronary artery disease and its entry into the European guidelines and South ...
Commonly prescribed drugs are prescribed according to guidelines around the world. For instance, for ischemic heart disease, the American College of Cardiology/American Heart Association (ACC/AHA) guideline is used in the United States and the European Society of Cardiology (ESC) guideline is used in Europe.
Drugs come with a recommended dose in milligrams or micrograms per kilogram of body weight, and that is used in conjunction with the patient's age and body weight to determine a safe dose. In single-dose scenarios, the patient's body weight and the drug's recommended dose per kilogram are used to determine a safe one-time dose.
For acute pseudogout, treatments include intra-articular corticosteroid injection, systemic corticosteroids, non-steroidal anti-inflammatory drugs (NSAIDs), or, on occasion, high-dose colchicine. [4] In general, NSAIDs are administered in low doses to help prevent CPPD. However, if an acute attack is already occurring, higher doses are ...
Colchicine is an alternative for those unable to tolerate NSAIDs. [20] At high doses, side effects (primarily gastrointestinal upset) limit its usage. [98] At lower doses, which are still effective, it is well tolerated. [39] [99] [96] [97] Colchicine may interact with other commonly prescribed drugs, such as atorvastatin and erythromycin ...