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An octreotide scan is a type of SPECT scintigraphy used to find carcinoid, pancreatic neuroendocrine tumors, and to localize sarcoidosis. It is also called somatostatin receptor scintigraphy (SRS). Octreotide , a drug similar to somatostatin , is radiolabeled with indium-111 , [ 1 ] and is injected into a vein and travels through the bloodstream.
Technetium (99m Tc) sestamibi (commonly sestamibi; USP: technetium Tc 99m sestamibi; trade name Cardiolite) is a pharmaceutical agent used in nuclear medicine imaging.The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six (sesta=6) methoxyisobutylisonitrile (MIBI) ligands.
[11] [12] 68 Ga DOTA-TATE imagery has a much higher sensitivity and resolution compared to 111 In octreotide gamma camera or SPECT scans, due to intrinsic modality differences. [11] It is commonly used to confirm the presence of paragangliomas and pheochromocytomas.
The Krenning score [1] is used to grade the uptake intensity of neuroendocrine tumors on somatostatin receptor imaging such as octreotide scan. [further explanation needed] Typically, peptide receptor radionuclide therapy (PRRT) is considered when the Krenning score is greater than 2.
Octreotide is a synthetic modification of somatostatin with a longer half-life. [ citation needed ] OctreoScan, also called somatostatin receptor scintigraphy (SRS or SSRS), utilizes intravenously administered octreotide that is chemically bound to a radioactive substance, often indium -111, to detect larger lesions with tumor cells that are ...
Gallium-68 DOTA scans are increasingly replacing octreotide scans (a type of indium-111 scan using octreotide as a somatostatin receptor ligand). The 68 Ga is bound to a chemical such as DOTATOC and the positrons it emits are imaged by PET-CT scan. Such scans are useful in locating neuroendocrine tumors and pancreatic cancer. [8]
The numbers 200-900 would be confused easily with 22 to 29 if they were used in chemistry. khīlioi = 1000, diskhīlioi = 2000, triskhīlioi = 3000, etc. 13 to 19 are formed by starting with the Greek word for the number of ones, followed by και (the Greek word for 'and'), followed by δέκα (the Greek word for 'ten').
The natural somatostatin receptor ligand, the 14 amino acid peptide somatostatin (A), was abridged to the biologically more stable 8 amino acid peptide Octreotide (OC, B). Introduction of a tyrosine into the 3rd position of the Octreotide sequence resulted in Tyr3-Octreotide (TOC, C), which allows for iodination of the tyrosine residue with the ...