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4-Piperidone is an organic compound with the molecular formula OC(CH 2) 4 NH. It can be viewed as a derivative of piperidine. 4-Piperidone is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs. Substituted and dehydro derivatives of 4-piperidinone are intermediates in alkaloid syntheses. [1]
N-Methyl-3-piperidyl benzilate (JB-336, BZ) Piperidine is also commonly used in chemical degradation reactions, such as the sequencing of DNA in the cleavage of particular modified nucleotides. Piperidine is also commonly used as a base for the deprotection of Fmoc-amino acids used in solid-phase peptide synthesis.
Melting point: 150 °C (302 °F; 423 K) Boiling point: 181 °C (358 °F; 454 K) ... 4-Pyridone is an organic compound with the formula C 5 H 4 NH(O ... 4-Piperidone ...
This page contains tables of azeotrope data for various binary and ternary mixtures of solvents. The data include the composition of a mixture by weight (in binary azeotropes, when only one fraction is given, it is the fraction of the second component), the boiling point (b.p.) of a component, the boiling point of a mixture, and the specific gravity of the mixture.
Boiling point (°C) K b (°C⋅kg/mol) Freezing point (°C) K f (°C⋅kg/mol) Data source; Aniline: 184.3 3.69 –5.96 –5.87 K b & K f [1] Lauric acid: 298.9 44 –3.9 Acetic acid: 1.04 117.9 3.14 16.6 –3.90 K b [1] K f [2] Acetone: 0.78 56.2 1.67 –94.8 K b [3] Benzene: 0.87 80.1 2.65 5.5 –5.12 K b & K f [2] Bromobenzene: 1.49 156.0 6. ...
N-Methyl-2-pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam. It is a colorless liquid, although impure samples can appear yellow. It is miscible with water and with most common organic solvents. It also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.
Paul Janssen (founder of Janssen Pharmaceutica) first synthesized fentanyl in 1960 from Benzylfentanyl. [4] The Siegfried method (shown below and published on The Hive ) involves reacting N -phenethyl-4-piperidinone with aniline , and then reducing the imine product with sodium borohydride to 4-anilino- N -phenethylpiperidine (ANPP).
2-Piperidinone (2-piperidone or δ-valerolactam) is an organic compound with the formula (CH 2) 4 CONH. Valerolactam is formed by dehydrogenation of 5-amino-1-pentanol, catalyzed by rhodium and ruthenium complexes, [3] [4] The compound, a colorless solid, is classified as a lactam. It is the monomer of nylon 5, a polyamide: n (CH 2) 4 CONH → ...