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It was discovered in 2000 as one of two improved mutants by H. Bujard and his colleagues after random mutagenesis of the Tet repressor part of the transactivator gene. [6] Tet-On 3G (also known as rtTA-V10 [7]) is similar to Tet-On Advanced but was derived from rtTA2 S-S2 rather than rtTA2 S-M2. It is also human codon optimized and composed of ...
Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes, in humans it is encoded by the TET1 gene.Its function, regulation, and utilizable pathways remain a matter of current research while it seems to be involved in DNA demethylation and therefore gene regulation, [5] [6] but is expressed as different isoforms which may have distinct functions.
Gene conversion is the process by which one DNA sequence replaces a homologous sequence such that the sequences become identical after the conversion. [1] Gene conversion can be either allelic , meaning that one allele of the same gene replaces another allele, or ectopic , meaning that one paralogous DNA sequence converts another.
In oxidative bisulfite sequencing (oxBS), Tet is used to convert 5-hydroxymethylcytosine to 5-formylcytosine, which subsequently converts to uracil during bisulfite treatment. [35] The only base that then reads as a C is 5‑methylcytosine, giving a map of the true methylation status in the DNA sample.
Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. [5] [6] Telomerases are part of a distinct subgroup of RNA-dependent polymerases.
LTR retrotransposons have direct long terminal repeats that range from ~100 bp to over 5 kb in size. LTR retrotransposons are further sub-classified into the Ty1-copia-like (Pseudoviridae), Ty3-like (Metaviridae, formally referred to as Gypsy-like, a name that is being considered for retirement [4]), and BEL-Pao-like (Belpaoviridae) groups based on both their degree of sequence similarity and ...
194388 Ensembl ENSG00000187605 ENSMUSG00000034832 UniProt O43151 Q8BG87 RefSeq (mRNA) NM_001287491 NM_001366022 NM_183138 NM_001347313 RefSeq (protein) NP_001274420 NP_001352951 NP_001334242 NP_898961 Location (UCSC) Chr 2: 73.98 – 74.11 Mb Chr 6: 83.34 – 83.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tet methylcytosine dioxygenase 3 is a protein that in humans is encoded ...
[1] [2] Tat is a regulatory protein that drastically enhances the efficiency of viral transcription. [2] Tat stands for "Trans-Activator of Transcription". The protein consists of between 86 and 101 amino acids depending on the subtype. [3] Tat vastly increases the level of transcription of the HIV dsDNA. Before Tat is present, a small number ...