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1071 n/a Ensembl ENSG00000087237 n/a UniProt P11597 n/a RefSeq (mRNA) NM_000078 NM_001286085 n/a RefSeq (protein) NP_000069 NP_001273014 n/a Location (UCSC) Chr 16: 56.96 – 56.98 Mb n/a PubMed search n/a Wikidata View/Edit Human Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and ...
A CETP inhibitor is a member of a class of drugs that inhibit cholesterylester transfer protein (CETP). [1] [2] ...
Cholesteryl ester is transported from high-density lipoproteins (HDLs) to low-density lipoproteins (LDLs) and very low-density lipoproteins (VLDLs) with cholesteryl ester transfer protein (CETP). [5] The decrease in cholesteryl ester can lower HDL and increase LDL, which may be an indicator of cardiovascular problems, as indicated by ...
Cholesteryl ester transfer protein (CETP) inhibitors include the agents torcetrapib, anacetrapib and obicetrapib. They block transfer of cholesterol from "good" HDL particles to "bad" LDL particles thereby causing an increase in the HDL:LDL ratio.
Dalcetrapib [4] (INN, codenamed JTT-705) is a CETP inhibitor which was originally being developed by F. Hoffmann–La Roche until May 2012. [5] [6] DalCor Pharmaceuticals licensed dalcetrapib as a potential pioneering precision medicine for patients with cardiovascular disease. By combining genetic and clinical insights into the development ...
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The cholesteryl esters can be transferred, with the help of CETP (cholesterylester transfer protein) in exchange for triglycerides, to ApoB-containing lipoproteins (LDL, VLDL, IDL). These other lipoproteins can be eventually taken up by the liver through their own receptors – an alternate route for liver uptake – or end up transporting the ...
It converts free cholesterol into cholesteryl ester, a more hydrophobic form of cholesterol. This process sequesters cholesterol ester into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface.