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  2. Sex-determining region Y protein - Wikipedia

    en.wikipedia.org/wiki/Sex-determining_region_y...

    In humans, the SRY gene is located on short (p) arm of the Y chromosome at position 11.2. Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals (placentals and marsupials). [5]

  3. Sexual differentiation in humans - Wikipedia

    en.wikipedia.org/wiki/Sexual_differentiation_in...

    The human Y chromosome showing the SRY gene which codes for a protein regulating sexual differentiation. Sexual differentiation in humans is the process of development of sex differences in humans . It is defined as the development of phenotypic structures consequent to the action of hormones produced following gonadal determination. [ 1 ]

  4. XX male syndrome - Wikipedia

    en.wikipedia.org/wiki/XX_male_syndrome

    The SRY gene, normally found on the Y chromosome, plays an important role in sex determination by initiating testicular development. In about 80 percent of XX males, the SRY gene is present on one of the X chromosomes. [16] [25] The condition results from an abnormal exchange of genetic material between chromosomes (translocation).

  5. SOX2 - Wikipedia

    en.wikipedia.org/wiki/SOX2

    6657 20674 Ensembl ENSG00000181449 ENSMUSG00000074637 UniProt P48431 P48432 RefSeq (mRNA) NM_003106 NM_011443 RefSeq (protein) NP_003097 NP_035573 Location (UCSC) Chr 3: 181.71 – 181.71 Mb Chr 3: 34.7 – 34.71 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self ...

  6. Sex-determination system - Wikipedia

    en.wikipedia.org/wiki/Sex-determination_system

    Once the SRY gene is activated, cells create testosterone and anti-müllerian hormone which typically ensures the development of a single, male reproductive system. [9] In typical XX embryos, cells secrete estrogen, which drives the body toward the female pathway. In Y-centered sex determination, the SRY gene is the main gene in determining ...

  7. Sexual differentiation - Wikipedia

    en.wikipedia.org/wiki/Sexual_differentiation

    Sexual differentiation is the process of development of the sex differences between males and females from an undifferentiated zygote. [1] [2] Sex determination is often distinct from sex differentiation; sex determination is the designation for the development stage towards either male or female, while sex differentiation is the pathway towards the development of the phenotype.

  8. XY gonadal dysgenesis - Wikipedia

    en.wikipedia.org/wiki/XY_gonadal_dysgenesis

    XY complete gonadal dysgenesis, also known as Swyer syndrome, is a type of defect hypogonadism in a person whose karyotype is 46,XY. Though they typically have normal vulvas, [1] the person has underdeveloped gonads, fibrous tissue termed "streak gonads", and if left untreated, will not experience puberty.

  9. SOX gene family - Wikipedia

    en.wikipedia.org/wiki/SOX_gene_family

    SOX genes (SRY-related HMG-box genes) encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box (for high mobility group). This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species.