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  2. Apixaban - Wikipedia

    en.wikipedia.org/wiki/Apixaban

    [15] [30] In March 2014, it was approved for the additional indication of preventing deep vein thrombosis and pulmonary embolism in people who have recently undergone knee or hip replacement. [31] [32] In August 2014, the FDA approved apixaban for the additional indication of the treatment of recurring deep vein thrombosis and pulmonary embolism.

  3. Pulmonary embolism - Wikipedia

    en.wikipedia.org/wiki/Pulmonary_embolism

    The pulmonary embolism rule-out criteria (PERC) helps assess people in whom pulmonary embolism is suspected, but unlikely. Unlike the Wells score and Geneva score , which are clinical prediction rules intended to risk stratify people with suspected PE, the PERC rule is designed to rule out the risk of PE in people when the physician has already ...

  4. Thromboembolism - Wikipedia

    en.wikipedia.org/wiki/Thromboembolism

    pulmonary embolism (PE) [3] [4] [5] BB00. VTE is a common cardiovascular disorder with significant morbidity and mortality. [3] [4] [5] VTE can present with various symptoms, such as painful leg swelling, chest pain, dyspnea, hemoptysis, syncope, and even death, depending on the location and extent of the thrombus.

  5. Venous thrombosis - Wikipedia

    en.wikipedia.org/wiki/Venous_thrombosis

    This carries a risk of bleeding and is therefore reserved for those who have a form of thrombosis that may cause major complications. In pulmonary embolism, this applies in situations where heart function is compromised due to lack of blood flow through the lungs ("massive" or "high risk" pulmonary embolism), leading to low blood pressure. [42]

  6. Thrombolysis - Wikipedia

    en.wikipedia.org/wiki/Thrombolysis

    Thrombolysis, also called fibrinolytic therapy, is the breakdown of blood clots formed in blood vessels, using medication.It is used in ST elevation myocardial infarction, stroke, and in cases of severe venous thromboembolism (massive pulmonary embolism or extensive deep vein thrombosis).

  7. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    The monitoring of warfarin and keeping the international normalized ratio (INR) between 2.0 and 3.0, along with avoiding over and under treatment, has driven a search for an alternative. [3] [14] A naturally occurring inhibitor of factor Xa was reported in 1971 by Spellman et al. from the dog hookworm. [15]