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Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. [4] [9] [10] Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, [11] a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals ...
The symptoms of Cushing's disease are similar to those seen in other causes of Cushing's syndrome. [5] Patients with Cushing's disease usually present with one or more signs and symptoms secondary to the presence of excess cortisol or ACTH. [6] Although uncommon, some patients with Cushing's disease have large pituitary tumors (macroadenomas).
Physically, it can cause fatigue, trouble sleeping and appetite changes. When stress becomes chronic and cortisol levels ... Mentally, it can lead to anxiety and depression, burnout at work, and ...
Another cause for Cushing's syndrome is adrenocortical carcinoma. This is a rare form of cancer with an incidence of 1-2 per million people annually. About 60% of these cancers produce hormones, with cortisol being the most frequent. Most patients present in an advanced disease state and the outcome is dismal. [7]
Patients with some disorders, including delayed sleep phase disorder, are often mis-diagnosed with primary insomnia; when a person has trouble getting to sleep and awakening at desired times, but has a normal sleep pattern once asleep, a circadian rhythm disorder is a likely cause.
Cortisol at high concentrations can cross-react and activate the mineralocorticoid receptor due to the non-selectivity of the receptor, leading to aldosterone-like effects in the kidney. This is what causes the hypokalemia, hypertension, and hypernatremia associated with the syndrome. Patients often present with severe hypertension and end ...
Absence of other causes of hypersomnia; The presence of positive MSLT tests. [32] [33] [34] The latest ICD-10 defines IH with long sleep time as a neurological disorder that is a rare sleep disorder characterized by prolonged sleep at night and extreme sleepiness during the day. There are no apparent causes. This disorder affects the ability to ...
It may come with insomnia or major depressive disorder, or indicate other mental disorders. [2] The consequences can negatively affect the health, cognition, energy level and mood of a person and anyone around. It increases the risk of human error, especially with technology. [3]