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Self-amplifying RNA (saRNA), also termed self-replicating RNA (srRNA), is a type of mRNA molecule engineered to replicate itself within host cells, enhancing protein expression and boosting the immune response, making it a promising tool for vaccines and other therapeutic applications. As a "next-generation" mRNA, saRNA is designed to achieve ...
To identify an saRNA that can activate a gene of interest, several saRNAs need to be designed within a 1- to 2-kbp promoter region by following a set of rules [3] [4] and tested in cultured cells. In some reports, saRNAs are designed in such a way to target non-coding transcripts that overlap the promoter sequence of a protein coding gene.
Walgreens began in 1901, when Charles Rudolph Walgreen purchased a small food front store on the corner of Bowen and Cottage Grove Avenues in Chicago, where he had worked as a pharmacist. [6] His energy and enthusiasm soon led to new ideas and ambitious expansion. For example, he manufactured his own line of drug products to ensure high quality ...
Walgreens offered low-priced lunch counters, built its own ice cream factory, and introduced the malted milk shake in 1922. By 1927, Walgreen had established 110 stores. His son Charles Rudolph Walgreen Jr. (March 4, 1906 – February 10, 2007) and grandson Charles R. Walgreen III both shared his name and played prominent roles in the company ...
Duane Reade Inc. (/ d w eɪ n ˈ r iː d / dwayn REED) is a chain of pharmacy and convenience stores owned by Walgreens.Its stores are primarily in New York (metropolitan New York City and Nassau, Suffolk, Westchester, Rockland, and Fairfield counties) in addition to in New Jersey.
Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCl) is a topical anesthetic discovered at Abbott Laboratories in 1953 [1] and used as an antipruritic.During research and development, pramocaine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent. [1]