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The liver transaminases aspartate transaminase (AST or SGOT) and alanine transaminase (ALT or SGPT) are useful biomarkers of liver injury in a patient with some degree of intact liver function. [2] [3] [4] Most liver diseases cause only mild symptoms initially, but these diseases must be detected early. Hepatic (liver) involvement in some ...
Aspartate transaminase (AST) This was the first used. [9] It is not specific for heart damage, and it is also one of the liver transaminases. Myoglobin (Mb) low specificity for myocardial infarction: 2 hours Myoglobin is used less than the other markers. Myoglobin is the primary oxygen-carrying pigment of muscle tissue.
Alanine transaminase is one of the two transaminases measured (Aspartate transaminase is the other). In medicine , the presence of elevated transaminases , commonly the transaminases alanine transaminase (ALT) and aspartate transaminase (AST), may be an indicator of liver dysfunction.
Aspartate transaminase (AST) or aspartate aminotransferase, also known as AspAT/ASAT/AAT or (serum) glutamic oxaloacetic transaminase (GOT, SGOT), is a pyridoxal phosphate (PLP)-dependent transaminase enzyme (EC 2.6.1.1) that was first described by Arthur Karmen and colleagues in 1954.
The AST/ALT ratio or De Ritis ratio is the ratio between the concentrations of two enzymes, aspartate transaminase (AST) and alanine transaminase, aka alanine aminotransferase (ALT), in the blood of a human or animal. It is used as one of several liver function tests, and measured with a blood test.
14718 Ensembl ENSG00000120053 ENSMUSG00000025190 UniProt P17174 P05201 RefSeq (mRNA) NM_002079 NM_010324 RefSeq (protein) NP_002070 NP_034454 Location (UCSC) Chr 10: 99.4 – 99.43 Mb Chr 19: 43.49 – 43.51 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Aspartate aminotransferase, cytoplasmic is an enzyme that in humans is encoded by the GOT1 gene. Glutamic-oxaloacetic transaminase ...
glutamate oxaloacetate transaminase (GOT), also called aspartate transaminase (AST), EC 2.6.1.1 (component of the malate aspartate shuttle) Recruited reaction steps of the citric acid cycle and malate aspartate shuttle
Asparagine synthetase (or aspartate-ammonia ligase) is a chiefly cytoplasmic enzyme that generates asparagine from aspartate. [1] This amidation reaction is similar to that promoted by glutamine synthetase. The enzyme is ubiquitous in its distribution in mammalian organs, but basal expression is relatively low in tissues other than the exocrine ...