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5-MeO-DMT is being developed and evaluated for potential therapeutic effects in patients with treatment-resistant depression (TRD). [57] Biopharmaceutical company GH Research has sponsored a completed phase 1 study in healthy volunteers [ 58 ] and phase 1/2 study in TRD patients where 87.5% of patients with TRD were brought into remission on ...
These two studies are some of the first large controlled studies measuring the effects of psychedelic therapy on depression and anxiety in cancer patients. [66] Across clinician-ratings and self-ratings, the psychedelic treatment produced statistically significant lowered anxiety and depression, with sustenance for at least 6 months.
CYB004, or CYB-004, also known as deuterated dimethyltryptamine (dDMT), is a serotonergic psychedelic related to dimethyltryptamine (DMT) which is under development for the treatment of generalized anxiety disorder. [1] [4] [2] [3] It is administered by inhalation or intravenous injection. [1] [2]
CYB003, or CYB-003, also known as deuterated psilocybin analogue, is a serotonergic psychedelic related to psilocybin which is under development for the treatment of major depressive disorder, alcoholism, and other psychiatric disorders.
C-DMT, also known as N,N-dimethyl-2-(3H-inden-1-yl)ethylamine, is a serotonin receptor agonist and a 3-indenyl ethyl amine derivative. [ 1 ] [ 2 ] [ 3 ] It is an analogue and bioisostere of the tryptamine psychedelic N , N -dimethyltryptamine (DMT) in which the indole ring has been replaced with an indene ring.
Upon approval, the following would join the program: dimethyltryptamine, or DMT, which is the active ingredient in ayahuasca; ibogaine, which studies show to help treat opioid addiction; bufotenin ...
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