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Tinidazole, sold under the brand name Tindamax among others, is a medication used against protozoan infections.It is widely known throughout Europe and the developing world as a treatment for a variety of anaerobic amoebic and bacterial infections.
The 5-nitroimidazole drugs (metronidazole and tinidazole) are the mainstay of treatment for infection with Trichomonas vaginalis. Treatment for both the infected patient and the patient's sexual partner is recommended, even if asymptomatic. Therapy other than 5-nitroimidazole drugs is also an option, but cure rates are much lower. [25]
In those with Giardia species or Entamoeba histolytica, tinidazole treatment is recommended and superior to metronidazole. [ 36 ] [ 76 ] The World Health Organization (WHO) recommends the use of antibiotics in young children who have both bloody diarrhea and fever.
Metronidazole 400 mg three times a day for 10 days; Tinidazole 2g once a day for 6 days is an alternative to metronidazole; Diloxanide furoate 500 mg three times a day for 10 days (or one of the other lumenal amebicides above) must always be given afterwards
Perhaps the most common example is metronidazole. Other heterocycles such as nitrothiazoles are also used for this purpose. Nitroheterocycles may be reductively activated in hypoxic cells, and then undergo redox recycling or decompose to toxic products. [5] Three nitroimidazole antibiotics: metronidazole, tinidazole, and nimorazole
The World Health Organisation and Infectious Disease Society of America recommend metronidazole as first-line therapy. [54] [55] The US CDC lists metronidazole, tinidazole, and nitazoxanide as effective first-line therapies; [56] of these three, only nitazoxanide and tinidazole are approved for the treatment of giardiasis by the US FDA.