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Mitochondrial biogenesis is the process by which cells increase mitochondrial numbers. [ 1 ] [ 2 ] It was first described by John Holloszy in the 1960s, when it was discovered that physical endurance training induced higher mitochondrial content levels, leading to greater glucose uptake by muscles. [ 3 ]
Mitochondria is a double-membrane structure in the body cell that generates and transports essential metabolic products. The three layers of this structure are the outer membrane, intermembrane space, and inner membrane. [2] The space inside the mitochondria is called the mitochondrial matrix, while the region outside is the cytosol.