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Brain+Natriuretic+Peptide at the U.S. National Library of Medicine Medical Subject Headings (MeSH) BNP and NT-proBNP at Lab Tests Online; Human NPPB genome location and NPPB gene details page in the UCSC Genome Browser. Overview of all the structural information available in the PDB for UniProt: P16860 (Natriuretic peptides B) at the PDBe-KB
N-terminal prohormone of brain natriuretic peptide (NT-proBNP or BNPT) is a 76 amino acid long protein that is cleaved from the N-terminal end of the 108 amino acid long prohormone proBNP to release brain natriuretic peptide 32 (BNP, also known as B-type natriuretic peptide). [1] [2] [3] [4]
The natriuretic peptide CNP was initially discovered in pig brain extracts. Most CNP is found in the brain, although it can also be found in chondrocytes and the blood vessel lining cells. The human gene for CNP (NPPC), in contrast to the genes for ANP and BNP, is located on chromosome 2 and consists of just two exons and one intron. [ 3 ]
Brain natriuretic peptide: BNP Peptide: heart [dubious – discuss] Cardiac myocytes: NPR (To a minor degree than ANP) reduce blood pressure by: reducing systemic vascular resistance, reducing blood water, sodium and fats. 19 Calcitonin: CT Peptide: thyroid gland: parafollicular cell: CT receptor → cAMP: Construct bone, reduce blood Ca 2+ 20 ...
Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide , brain natriuretic peptide , and C-type natriuretic peptide (CNP), encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood ...
Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C), also known as NPR3, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR3 gene . [ 5 ]
18160 Ensembl ENSG00000169418 ENSMUSG00000027931 UniProt P16066 P18293 RefSeq (mRNA) NM_000906 NM_008727 RefSeq (protein) NP_000897 NP_032753 Location (UCSC) Chr 1: 153.68 – 153.69 Mb Chr 3: 90.36 – 90.37 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial ...
In patients with non-severe asymptomatic aortic valve stenosis, increased age- and sex-adjusted N-terminal pro-brain natriuretic peptide levels alone and combined with a 50% or greater increase from baseline had been found associated with increased event rates of aortic valve stenosis related events (cardiovascular death, hospitalization with ...