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The uncertainty and variability in the dose–response relationship of dioxins in terms of their toxicity, as well as the ability of dioxins to bioaccumulate, have led WHO experts to recommending very low tolerable daily intake (TDI) of dioxin, 1-4 pg/kg body weight per day, i.e. 7x10 −11 to 2.8x10 −10 g per 70-kg person per day, to allow ...
They are commonly but inaccurately referred to as dioxins for simplicity, because every PCDD molecule contains a dibenzo-1,4-dioxin skeletal structure, with 1,4-dioxin as the central ring. Members of the PCDD family bioaccumulate in humans and wildlife because of their lipophilic properties, and may cause developmental disturbances and cancer .
With over 35,000 Amazon reviews, the mouthwash maintains a 4.6-star rating. “This stuff is a miracle!” one reviewer writes. “After one use, my husband’s breath was fresh, no after-odor.
TCDD and dioxin-like compounds act via a specific receptor present in all cells: the aryl hydrocarbon (AH) receptor. [6] [7] [8] This receptor is a transcription factor which is involved in the expression of genes; it has been shown that high doses of TCDD either increase or decrease the expression of several hundred genes in rats. [9]
Dibenzo-1,4-dioxin, also known as dibenzodioxin or dibenzo-p-dioxin (molecular formula C 12 H 8 O 2), in which two benzene rings are connected through two oxygen atoms. That is the parent compound of the dioxins (see next in which the dioxins comprise a key part of the class).
Listerine (/ ˈ l ɪ s t ər iː n /) is a brand of antiseptic mouthwash that is promoted with the slogan "Kills germs that cause bad breath". Named after Joseph Lister, who pioneered antiseptic surgery at the Glasgow Royal Infirmary in Scotland, Listerine was developed in 1879 by Joseph Lawrence, a chemist in St. Louis, Missouri.