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Hydrazine is an inorganic compound with the chemical formula N 2 H 4.It is a simple pnictogen hydride, and is a colourless flammable liquid with an ammonia-like odour.Hydrazine is highly hazardous unless handled in solution as, for example, hydrazine hydrate (N 2 H 4 ·xH 2 O).
Later randomized controlled trials failed to find any improvement in survival, [27] [28] For example, in a trial of the treatment of advanced lung cancer, with either cisplatin and vinblastine or these drugs plus hydrazine sulfate, saw complete tumor regression in 4% of the hydrazine group, versus 3% in the control group, and tumor progression ...
It can be derived from hydrazine by protonation (treatment with a strong acid). Hydrazinium is a weak acid with pK a = 8.1. Salts of hydrazinium are common reagents in chemistry and are often used in certain industrial processes. [1] Notable examples are hydrazinium hydrogensulfate, N 2 H 6 SO 4 or [N 2 H 5] + [HSO 4] −, and hydrazinium azide ...
There are various methods to synthesize aryl azides. One such method would be to set use react aniline with sodium nitrite (NaNO 2) and hydrazine hydrate in the presence of acetic acid. [2] This reaction will give moderate to good yield of the desired aryl azide. The best solvent for this reaction is dichloromethane.
R 2 C=N−NR' 2 + H 2 O → R 2 C=O + H 2 N−NR' 2. Alkyl hydrazones are 10 2 - to 10 3-fold more sensitive to hydrolysis than analogous oximes. [10] When derived from hydrazine itself, hydrazones condense with a second equivalent of a carbonyl to give azines: [11] R 2 C=N−NH 2 + R 2 C=O → R 2 C=N−N=CR 2 + H 2 O. Hydrazones are ...
Ketazines are also important intermediates in the industrial production of hydrazine hydrate by the peroxide process. [3] In the presence of an oxidant, ammonia and ketones react to give hydrazine via ketazine: 2 Me(Et)C=O + 2 NH 3 + H 2 O 2 → Me(Et)C=NN=C(Et)Me + 2 H 2 O. The ketazine can be hydrolyzed to the hydrazine and regenerate the ketone:
Aerozine continues in wide use as a rocket fuel, typically with dinitrogen tetroxide (N 2 O 4) as the oxidizer, with which it is hypergolic. Aerozine 50 is more stable than hydrazine alone, and has a higher density and boiling point than UDMH alone. Pure hydrazine has a higher performance than Aerozine 50, but an inconvenient freezing point of ...
Hydroxyzine can also be used for the treatment of allergic conditions, such as chronic urticaria, atopic or contact dermatoses, and histamine-mediated pruritus. [medical citation needed] These have also been confirmed in both recent and past studies to have no adverse effects on the liver, blood, nervous system, or urinary tract.