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Postherpetic neuralgia is the most common long-term complication of herpes zoster, and occurs in approximately 20% of patients with shingles. [2] Risk factors for PHN include older age, severe prodrome or rash, severe acute zoster pain, ophthalmic involvement, immunosuppression, and chronic conditions such as diabetes mellitus and lupus. [1]
The short- and long-term pain caused by shingles outbreaks originates from inflammation of affected nerves due to the widespread growth of the virus in those areas. [47] As with chickenpox and other forms of alpha-herpesvirus infection, direct contact with an active rash can spread the virus to a person who lacks immunity to it.
Shingles is a viral infection—caused by the same virus as chickenpox—that ... Adults over 65 should get the ... Vaccines can prevent severe illness and their long-term side effects.” ...
The degree of longer term protection (beyond 4 years from the initial vaccination) is not clear. The need for re-vaccination after the first full vaccine schedule is complete remains to be confirmed. [23] Zostavax was shown to reduce the incidence of shingles by 51% in a study of 38,000 adults aged 60 and older who received the vaccine.
After chickenpox resolves, the virus remains in the body. Anyone who has had chickenpox still carries the VZV virus, and may develop shingles unless they are vaccinated against it.
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