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Antipsychotic abuse refers to the non-medical or inappropriate use of antipsychotic medications for purposes other than their intended therapeutic use. Antipsychotics, also known as neuroleptics, are a class of medications primarily used in treating psychiatric disorders such as schizophrenia , bipolar disorder , and certain types of depression .
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Peak levels of quetiapine occur 1.5 hours after a dose. [86] The plasma protein binding of quetiapine is 83%. [86] The major active metabolite of quetiapine is norquetiapine (N-desalkylquetiapine). [67] Quetiapine has an elimination half-life of 6 or 7 hours. [86] [7] [8] Its metabolite, norquetiapine, has a half-life of 9 to 12 hours.
In case reports, quetiapine has been abused in doses taken by mouth (which is how the drug is available from the manufacturer), but also crushed and insufflated or mixed with water for injection into a vein. [294] Olanzapine, another sedating second-generation antipsychotic, has also been misused for similar reasons. [294]
The antipsychotic quetiapine is typically dosed two to three times daily for the management of schizophrenia. [3] A simpler regimen would be a once daily administered antipsychotic. [1] For example, risperidone can be administered once daily. [4] A lack of adherence can lead to poor health outcomes, as well as unnecessary financial burden. [5]
Psychomotor agitation is typically found in various mental disorders, especially in psychotic and mood disorders. It can be a result of drug intoxication or withdrawal. It can also be caused by severe hyponatremia. People with existing psychiatric disorders and men under the age of 40 are at a higher risk of developing psychomotor agitation. [2]
After attending AA meetings in Southern California in the late 1950s, he grew to believe that they were not tough enough. The addict needed more than brotherhood. He needed to be challenged, and “to grow up.” After a singular LSD experience, Dederich conjured up a drug-free commune for heroin addicts in Santa Monica.
In July 2013, the FDA issued a boxed warning for the antimalarial drug mefloquine, noting the drug's adverse neuropsychiatric side effects, and emphasizing neurological effects from the drug could "occur at any time during drug use, and can last for months to years after the drug is stopped or can be permanent". [23]
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