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Immortalised cell lines are widely used as a simple model for more complex biological systems – for example, for the analysis of the biochemistry and cell biology of mammalian (including human) cells. [2] The main advantage of using an immortal cell line for research is its immortality; the cells can be grown indefinitely in culture.
This is an accepted version of this page This is the latest accepted revision, reviewed on 7 February 2025. African-American woman (1920–1951), source of HeLa immortal cell line "Lacks" redirects here. For other uses, see Lack. Henrietta Lacks Lacks c. 1945–1951. Born Loretta Pleasant (1920-08-01) August 1, 1920 Roanoke, Virginia, U.S. Died October 4, 1951 (1951-10-04) (aged 31) Baltimore ...
TF-1 cells are an immortal cell line derived from the human Erythroleukemia used in biomedical research. [1] This cells are proliferatively responsive to interleukin-3 (IL-3) or granulocyte-macrophage colony-stimulating factor (GM-CSF). [2] TF-1 cells have gene fusion of CBFA2T3-ABHD12. [3]
The story of how the HeLa cell line came to be was also the subject of a 2010 episode of the podcast Radiolab. [69] HeLa cells were the subject of a 2010 book by Rebecca Skloot, The Immortal Life of Henrietta Lacks, investigating the historical context of the cell line and how the Lacks family was involved in its use. [14]
Human embryonic kidney 293 cells, also often referred to as HEK 293, HEK-293, 293 cells, are an immortalised cell line derived from HEK cells isolated from a female fetus in the 1970s. [ 1 ] [ 2 ] The HEK 293 cell line has been widely used in research for decades due to its reliable and fast growth and propensity for transfection .
The first and still most widely used immortal cell line is HeLa, developed from cells taken from the malignant cervical tumor of Henrietta Lacks without her consent in 1951. Prior to the 1961 work of Leonard Hayflick, there was the erroneous belief fostered by Alexis Carrel that all normal somatic cells are immortal. By preventing cells from ...
The book is about Henrietta Lacks and the immortal cell line, known as HeLa, that came from Lacks's cervical cancer cells in 1951. Skloot became interested in Lacks after a biology teacher referenced her but knew little about her. Skloot began conducting extensive research on her and worked with Lacks' family to create the book.
Since the original CHO cell line was described in 1956, many variants of the cell line have been developed for various purposes. [10] [additional citation(s) needed] In 1957, CHO-K1 was generated from a single clone of CHO cells. [16] According to an industry source, however, scientist Theodore Puck first isolated CHO-K1 in 1968. [1]