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Erythromelalgia in hands of a Scandinavian male, 52, after holding a book). The most prominent symptoms of erythromelalgia are episodes of erythema, swelling, a painful deep-aching of the soft tissue (usually either radiating or shooting) and tenderness, along with a painful burning sensation primarily in the extremities. These symptoms are ...
When impaired vein function leads to significant symptoms such as oedema (swelling) or venous ulcer formation, the condition is referred to as chronic venous disease. [3] It is also known as chronic peripheral venous insufficiency and should not be confused with post-thrombotic syndrome , a separate condition caused by damage to the deep veins ...
PEPD symptoms are reminiscent of primary erythromelalgia, as both result in flushing and episodic pain, though pain is typically present in the extremities for primary erythromelalgia. Both of these disorders have recently been shown to be allelic, both caused by mutations in the voltage-gated sodium channel Na V 1.7 encoded by the gene SCN9A .
Necrotic muscle fibers are swollen and eosinophilic and lack striations and nuclei. Small-vessel walls are thickened and hyalinized , with luminal narrowing or complete occlusion. Biopsy cultures for bacteria , fungi , acid-fast bacilli and stains are negative in simple myonecrosis.
People with thrombophlebitis complain of pain along the affected area. Some report constitutional symptoms, such as low-grade fever and aches. On physical examination, the skin over the affected vein exhibits erythema, warmth, swelling, and tenderness. Later in the disease, as induration subsides, erythema gives way to a ruddy or bruised color ...
Proximal diabetic neuropathy, also known as diabetic amyotrophy, is a complication of diabetes mellitus that affects the nerves that supply the thighs, hips, buttocks and/or lower legs. Proximal diabetic neuropathy is a type of diabetic neuropathy characterized by muscle wasting, weakness, pain, or changes in sensation/numbness of the leg.
Erythromelalgia is a rare symptom of PV, here present in a patient with longstanding polycythemia vera. Note reddish limbs and swelling. People with polycythemia vera can be asymptomatic. [4] Clinical symptoms of polycythemia vera are mostly due to hyperviscosity of blood.
The cause of this degeneration is unknown, but likely accounts for some of the signs and symptoms of the disorder, such as the loss of temperature differentiation and pin-prick sensation. The combination of increased pain signaling, and degeneration of pain-transmitting fibers, leads to a variable condition with signs and symptoms that can both ...
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