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Phentermine (Adipex-P®, Lomaira®). Phentermine is a stimulant that suppresses appetite by affecting the central nervous system. ... Consider reviews from people who’ve used it successfully (or ...
Phentermine is an norepinephrine and dopamine releasing agent (NDRA) and produces stimulant, rewarding, and appetite suppressant effects. [8] [9] [10] Chemically, it is a substituted amphetamine. [11] Phentermine was approved for medical use in the United States in 1959. [3] It is available as a generic medication. [3]
In 1959, phentermine had been FDA approved and fenfluramine in 1973. In the early 1990s two studies found that a combination of the drugs was more effective than either on its own; fen-phen became popular in the United States and had more than 18 million prescriptions in 1996. [ 40 ]
Phentermine and topiramate was developed by Vivus, a California pharmaceutical company. In December 2009, Vivus, Inc. submitted a new drug application (NDA) to the FDA and on 1 March 2010, Vivus, Inc. announced that the FDA accepted the NDA for review.
[11] [18] A few other MRAs have also been found to be inactive at VMAT2, such as phentermine and benzylpiperazine (BZP). [11] [18] These findings indicate that VMAT2 activity is non-essential for robust MRA actions. [11] [18] Phenmetrazine does not appear to have been assessed at the trace amine-associated receptor 1 (TAAR1). [19] [20]
In 1984, researchers at the University of Rochester Medical Center reported that they had performed a double-blind, controlled clinical trial comparing phentermine alone, fenfluramine alone, a combination of phentermine and fenfluramine, and placebo, for weight loss in humans. Weight loss in those receiving the fen-phen combination was ...
Amfepramone, also known as diethylpropion, is a stimulant drug of the phenethylamine, amphetamine, and cathinone classes that is used as an appetite suppressant. [8] [9] It is used in the short-term management of obesity, along with dietary and lifestyle changes. [8]
Fastin was once a brand name of a drug called phentermine and the Fastin brand of phentermine was manufactured by King Pharmaceuticals. Fastin and 10 other products manufactured by Hi Tech Pharmaceuticals were banned by the U.S. Food and Drug Administration (FDA) in 2013 because they contain Dimethylamylamine HCl (DMAA), an illegal food ...