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Adie syndrome, also known as Holmes–Adie syndrome, is a neurological disorder characterized by a tonically dilated pupil that reacts slowly to light but shows a more definite response to accommodation (i.e., light-near dissociation). [1] It is frequently seen in females with absent knee or ankle jerks and impaired sweating.
Adie's pupil is caused by damage to peripheral pathways to the pupil (parasympathetic neurons in the ciliary ganglion that cause pupillary constriction to bright light and with near vision). The pathophysiologic mechanism which produces an Argyll Robertson pupil is unclear, but is believed to be the result of bilateral damage to the pretectal ...
Holmes and Adie shared interests in neurology and neuroanatomy, and in 1941 they published separate papers on the condition. The condition now bears their conjoined eponym, Holmes-Adie syndrome. [12] In the period between the wars, Holmes had concurrent appointments at Queen Square, Moorfields Eye Hospital and the Charing Cross Hospital. He was ...
Adie pupil: William John Adie: neurology: ciliary nerve damage: dilated pupil, poorly reactive but with normal near accommodation Adson's sign: Alfred Washington Adson: vascular surgery: thoracic outlet syndrome: obliteration of radial pulse with manoeuvres Alexander's law: Gustav Alexander: neurology, neurosurgery, ENT: vestibular lesions
Adie syndrome [4] is tonic pupil plus absent deep tendon reflexes. Adie syndrome is a fairly common, benign, idiopathic neuropathy that selectively affects the ciliary ganglion and the spinal cord neurons involved in deep tendon reflex arcs.
Adie tonic pupil: Tonic pupil is usually an isolated benign entity, presenting in young women. It may be associated with loss of deep tendon reflex (Adie's syndrome). Tonic pupil is characterized by delayed dilation of the iris, especially after near stimulus, segmental iris constriction, and sensitivity of pupil to a weak solution of pilocarpine.
In 1932 Adie was one of the founders of the Association of British Neurologists, which was formed at a meeting on 28 July at the house of Gordon Holmes. [6] Adie was known as an excellent teacher of medicine and a fine diagnostician with extraordinary powers of observation. [2] His interests also included ornithology, tennis and skiing. [1]
Marcus Gunn pupil: The left optic nerve and the optic tracts. A Marcus Gunn pupil indicates an afferent defect, usually at the level of the retina or optic nerve. Moving a bright light from the unaffected eye to the affected eye would cause both eyes to dilate, because the ability to perceive the bright light is diminished. Specialty