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Dyskeratosis is abnormal keratinization occurring prematurely within individual cells or groups of cells below the stratum granulosum. [ 1 ] Dyskeratosis congenita is congenital disease characterized by reticular skin pigmentation, nail degeneration, and leukoplakia on the mucous membranes associated with short telomeres .
Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, [1] seen in diseases such as pemphigus vulgaris. [2]
Grover's disease (GD) is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis [2]: 529 with or without dyskeratosis. [3] Once confirmed, most cases of Grover's disease last six to twelve months, which is why it was originally called "transient". However it may last much longer.
A vesiculobullous disease is a type of mucocutaneous disease characterized by vesicles and bullae (i.e. blisters).Both vesicles and bullae are fluid-filled lesions, and they are distinguished by size (vesicles being less than 5–10 mm and bulla being larger than 5–10 mm, depending upon which definition is used).
Warty dyskeratoma. Warty dyskeratoma, also known as an Isolated dyskeratosis follicularis, [1]: 777 is a benign [2] epidermal proliferation with distinctive histologic findings that may mimic invasive squamous cell carcinoma [3] and commonly manifests as an umbilicated (Having a central mark or depression resembling a navel) lesion with a keratotic plug, [4] WD have some histopathologic ...
Acantholytic dyskeratotic epidermal nevus is a cutaneous condition identical to the generalized form of Darier's disease. [ 1 ] : 849 "Acantholytic dyskeratotic epidermal nevus" is probably the same disorder.
Pemphigus vulgaris (PV - ICD-10 L10.0) is the most common form of the disorder and occurs when antibodies attack desmoglein 3. Sores often originate in the mouth, making eating difficult and uncomfortable. Although PV may occur at any age, it is most common among people between 40 and 60. It is more frequent among Ashkenazi Jews.
Apoptotic and necrotic cells, absence of acantholytic cells A Tzanck smear may be a rapid test to distinguish toxic epidermal necrolysis from SSSS III. Genodermatoses: Hailey-Hailey disease: Acantholytic cells without direct immunofluorescence positivity Direct immunofluorescence examination should be made for differentiation from pemphigus.