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Oral lichen planus (also termed oral mucosal lichen planus), is a form of mucosal lichen planus, where lichen planus involves the oral mucosa, the lining of the mouth. [39] This may occur in combination with other variants of lichen planus. Six clinical forms of oral lichen planus (OLP) are recognized: [40] Reticular
PITTSBURGH, Aug. 22, 2024 (GLOBE NEWSWIRE) -- Lipella Pharmaceuticals, Inc. (NASDAQ: LIPO) has launched an Oral Lichen Planus (OLP) Patient Registry. This online platform is designed to enhance research and drive the development of new treatments for OLP, a chronic inflammatory disease affecting the mucous membranes of the mouth.
Lichen planus: A chronic inflammatory disease with different forms of oral presentations. The most classic appearance of lichen planus is the presence of white streaks in inner cheek, tongue, and gum. Desquamative gingivitis can be seen in patients with lichen planus. Biopsy is done for definitive diagnosis of lichen planus. [18] [23]
Desquamative gingivitis is a descriptive clinical term, not a diagnosis. [1] Dermatologic conditions cause about 75% of cases of desquamative gingivitis, and over 95% of the dermatologic cases are accounted for by either oral lichen planus or cicatricial pemphigoid. [1]
Wickham striae or Wickham's striae are whitish lines visible in the papules of lichen planus and other dermatoses, typically in the oral mucosa. [1] The microscopic appearance shows hypergranulosis. They are named after Louis Frédéric Wickham. [2] [3]
Lichenoid eruptions are dermatoses related to the unique, common inflammatory disorder lichen planus, which affects the skin, mucous membranes, nails, and hair. [74] [75] [76] Annular lichen planus Lichen planus actinicus; Atrophic lichen planus; Bullous lichen planus (vesiculobullous lichen planus) Erosive lichen planus
The differential diagnosis is with leukoplakia, oral candidiasis, oral lichen planus, white sponge nevus, morsicatio buccarum, [3] hereditary benign intraepithelial dyskeratosis and dyskeratosis congenita.
[20] [21] The condition resembles oral lichen planus when biopsied. The diagnosis is made by microscopic examination of biopsy tissue: direct immunofluorescence can reveal the presence of antinuclear antibodies specifically directed against the ΔNp63α form of the p63 protein , which is normally expressed within the basal layer of stratified ...