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Drugs can have various types of impact on the male body, side effects of medications may affect male fertility, spermatogenesis, and sexual function. Drugs can affect sperm parameters by inhibiting normal exocrine functions of the testes which can lead to a decrease in production of sperm, or by creating hormone imbalances. [4]
Spermatogenesis produces mature male gametes, commonly called sperm but more specifically known as spermatozoa, which are able to fertilize the counterpart female gamete, the oocyte, during conception to produce a single-celled individual known as a zygote.
Usually, affected men show no symptoms, although they may have smaller testes. Men with this condition may exhibit azoospermia (no sperm production), oligozoospermia (small number of sperm production), or they may produce abnormally shaped sperm (teratozoospermia). [22] This case of infertility occurs during the development of gametes in the male.
Human sexual reproduction, to produce offspring, begins with fertilization. Successful reproduction typically involves sexual intercourse between a healthy, sexually mature and fertile male and female. [1] During sexual intercourse, sperm cells are ejaculated into the vagina through the penis, resulting in fertilization of an ovum to form a ...
Vasectomy is an elective surgical procedure that results in male sterilization, often as a means of permanent contraception.During the procedure, the male vasa deferentia are cut and tied or sealed so as to prevent sperm from entering into the urethra and thereby prevent fertilization of a female through sexual intercourse.
As Romanis notes, for most of the 20th century, “the focus was, how do we stop the person getting pregnant, as opposed to how do we stop the sperm being viable in the first place.
Spermatocytogenesis is the male form of gametocytogenesis and involves stem cells dividing to replace themselves and to produce a population of cells destined to become mature sperm. The stem cells involved are called spermatogonia and are a specific type of stem cell known as gametogonia.
Azoospermia is the medical condition of a man whose semen contains no sperm. [1] It is associated with male infertility, but many forms are amenable to medical treatment.In humans, azoospermia affects about 1% of the male population [2] and may be seen in up to 20% of male infertility situations in Canada.