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The metabolism of anastrozole is by N-dealkylation, hydroxylation, and glucuronidation. [3] Inhibition of aromatase is due to anastrozole itself rather than to metabolites, with the major circulating metabolite being inactive. [6] The elimination half-life of anastrozole is 40 to 50 hours (1.7 to 2.1 days).
Ovarian stimulation with the aromatase inhibitor letrozole has been proposed for ovulation induction in order to treat unexplained female infertility. In a multi-center study funded by the National Institute of Child Health and Development, ovarian stimulation with letrozole resulted in a significantly lower frequency of multiple gestation (i.e., twins or triplets) but also a lower frequency ...
These side effects may occur in as many as 90% of men treated with bicalutamide monotherapy, [29] but gynecomastia is generally reported to occur in 70 to 80% of patients. [30] In the EPC trial, at a median follow-up of 7.4 years, breast pain and gynecomastia respectively occurred in 73.6% and 68.8% of men treated with 150 mg/day bicalutamide ...
Women post-menopause with ‘strong family history’ of breast cancer encouraged speak to GP about drug, expert says
Steroidal aromatase inhibitors are a class of drugs that are mostly used for treating breast cancer in postmenopausal women. High levels of estrogen in breast tissue increases the risk of developing breast cancer and the enzyme aromatase is considered to be a good therapeutic target when treating breast cancer due to it being involved in the final step of estrogen biosynthetic pathway and also ...
Zinc and vitamin D are also essential for bone health but have the added benefit for men over 50 by reducing the risk of erectile dysfunction, a condition commonly affecting men over age 40 ...
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