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Drug titration is the process of adjusting the dose of a medication for the maximum benefit without adverse effects. [ 1 ] When a drug has a narrow therapeutic index , titration is especially important, because the range between the dose at which a drug is effective and the dose at which side effects occur is small. [ 2 ]
The first-line treatment choice today to treat BPH is tamsulosin. It is not better tolerated, nor does it have greater efficacy than the previous drugs, however, it requires minimal dose titration in comparison. Alfuzosin SR (sustained release) was the fourth alpha 1 selective blocker to be approved by FDA and requires no dose titration. [2] [47]
Imiquimod, sold under the brand name Aldara among others, is a medication that acts as an immune response modifier that is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis.
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Careful titration of oxygen supply to minimise the excess to physiological need also reduces pulmonary hyperoxic exposure to the reasonably practicable minimum. [38] The incidence of pulmonary symptoms of oxygen toxicity is about 5%, and some drugs can increase the risk, such as the chemotherapeutic agent bleomycin.
Van Tuong Nguyen (Vietnamese: Nguyễn Tường Vân, listen ⓘ; 17 August 1980 – 2 December 2005), baptised Caleb, [1] was an Australian from Melbourne, Victoria convicted of drug trafficking in Singapore.
A titration curve is a curve in graph the x-coordinate of which represents the volume of titrant added since the beginning of the titration, and the y-coordinate of which represents the concentration of the analyte at the corresponding stage of the titration (in an acid–base titration, the y-coordinate usually represents the pH of the solution).
Voxelotor was granted accelerated approval by the US Food and Drug Administration (FDA) in November 2019. [12] [11] [18] The FDA granted the application for voxelotor fast track designation and orphan drug designation. [11] [19] The approval of voxelotor was based on the results of a clinical trial with 274 participants with sickle cell disease ...