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Credé prophylaxis is the practice of washing a newborn's eyes with a 2% silver nitrate solution to protect against neonatal conjunctivitis caused by Neisseria gonorrhoeae, thereby preventing blindness. [1] The Credé procedure was developed by the German physician Carl Siegmund Franz Credé who implemented it in his hospital in Leipzig in 1880 ...
A typical reaction with silver nitrate is to suspend a rod of copper in a solution of silver nitrate and leave it for a few hours. The silver nitrate reacts with copper to form hairlike crystals of silver metal and a blue solution of copper nitrate: 2 AgNO 3 + Cu → Cu(NO 3) 2 + 2 Ag. Silver nitrate decomposes when heated:
During a three-year period, Credé treated 1160 newborns with silver nitrate, with only 0.15% of the infants developing ophthalmia. [2] The silver nitrate solution is sometimes referred to as "Credé's prophylaxis" in medical literature, and other eyedrop prophylactics (for example, antibiotics) are still called by the same name. Later, the ...
Silver compounds have been used in external preparations as antiseptics, including both silver nitrate and silver proteinate. Before the development of antibiotics, Credé's prophylaxis used a 2% solution of silver nitrate to prevent neonatal conjunctivitis, which used to account for half of all cases of blindness in Europe.
This may be erythromycin, tetracycline, or rarely silver nitrate [3] or Argyrol (mild silver protein). The use of 1-2% silver nitrate solution was introduced in 1881 by Credé as Credé's prophylaxis. [3] [12] [13] [14] Prophylaxis needs antenatal, natal, and postnatal care.
Immerse a block (approx. 10x5 mm) of formaldehyde-fixed (or paraformaldehyde- glutaraldehyde-perfused) brain tissue into a 2% aqueous solution of potassium dichromate for 2 days; Dry the block shortly with filter paper. Immerse the block into a 2% aqueous solution of silver nitrate for another 2 days. Cut sections approx. 20–100 μm thick.