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These side effects may occur in as many as 90% of men treated with bicalutamide monotherapy, [29] but gynecomastia is generally reported to occur in 70 to 80% of patients. [30] In the EPC trial, at a median follow-up of 7.4 years, breast pain and gynecomastia respectively occurred in 73.6% and 68.8% of men treated with 150 mg/day bicalutamide ...
Classification and diagnosis of the underlying disease of hyperbilirubinemia are crucial for prescription of treatment. [6]Physical examination reviews clinical symptoms like degree of jaundice, vital signs and sensations of pain, further followed by urine tests, blood analysis and imaging.
Gilbert syndrome is a phenotypic effect, mostly associated with increased blood bilirubin levels, but also sometimes characterized by mild jaundice due to increased unconjugated bilirubin, that arises from several different genotypic variants of the gene for the enzyme responsible for changing bilirubin to the conjugated form.
Conjugated bilirubin is normally stored in the gallbladder as a constituent of bile and is excreted through the intestines; it does not occur at detectable levels in the urine. [81] The presence of bilirubin in the urine (termed bilirubinuria) occurs as a consequence of high blood levels of conjugated bilirubin in liver disease or bile duct ...
Jaundice, also known as icterus, is a yellowish or greenish pigmentation of the skin and sclera due to high bilirubin levels. [3] [6] Jaundice in adults is typically a sign indicating the presence of underlying diseases involving abnormal heme metabolism, liver dysfunction, or biliary-tract obstruction. [7]
Younger age, female, immunocompromised, or existing renal, urinary, or lower GI disease (because these are the systems involved in the disease) [1] Diagnostic method: Blood tests (to monitor levels of platelets, red blood cells, and white blood cells), stool tests (especially to check for microscopic or macroscopic levels of fresh or old blood ...
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