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Benzamide is an organic compound with the chemical formula of C 7 H 7 NO. It is the simplest amide derivative of benzoic acid . In powdered form, it appears as a white solid, while in crystalline form, it appears as colourless crystals. [ 5 ]
Benzamidine is a reversible competitive inhibitor of trypsin, trypsin-like enzymes, and serine proteases. [4]It is often used as a ligand in protein crystallography to prevent proteases from degrading a protein of interest.
Antipsychotics by class Generic name Brand names Chemical class ATC code Typical antipsychotics; Acepromazine: Atravet, Acezine: phenothiazine: N05AA04
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Amisulpride is a benzamide derivative. It is structurally related to other benzamide dopamine receptor antagonists employed as antipsychotics and antiemetics including levosulpiride , metoclopramide , nemonapride , remoxipride , sulpiride , sultopride , tiapride , and veralipride .
It is a benzamide HDI and inhibits Class I HDAC1, HDAC2, HDAC3, as well as Class IIb HDAC10. [3] Tucidinostat is approved by the Chinese FDA for relapsed or refractory peripheral T-cell lymphoma (PTCL) and has orphan drug status in Japan.
Itopride (INN; brand name Ganaton) is a prokinetic benzamide derivative. These drugs inhibit dopamine and acetylcholine esterase enzyme and have a gastrokinetic effect. [ 3 ] Itopride is indicated for the treatment of functional dyspepsia and other gastrointestinal conditions. [ 4 ]
Entinostat, also known as SNDX-275 and MS-275, is a benzamide histone deacetylase inhibitor undergoing clinical trials for treatment of various cancers. [1] [2] [3] [4]