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Aseptic processing was derived from Olin Ball's heat-cool-fill (HCF) machine that was developed in 1927. [5] While HCF was successful in improving the sensory quality of the processed chocolate milk as compared to canned product, the use of the equipment was hindered by its cost, maintenance, and inflexibility to process various container sizes, rendering the machine a failure.
The SDSCS classifies sterilization techniques into three categories: critical, semi-critical, and non-critical. [3] For critical situations, or situations involving contact with sterile tissue or the vascular system, sterilize devices with sterilants that destroy all bacteria, rinse with sterile water, and use chemical germicides.
Universal precautions are an infection control practice. Under universal precautions all patients were considered to be possible carriers of blood-borne pathogens. The guideline recommended wearing gloves when collecting or handling blood and body fluids contaminated with blood, wearing face shields when there was danger of blood splashing on mucous membranes ,and disposing of all needles and ...
While all members of the surgical team should demonstrate good aseptic technique, it is the role of the scrub nurse or surgical technologist to set up and maintain the sterile field. [ 13 ] [ 14 ] To prevent cross-contamination of patients, instruments are sterilized through autoclaving or by using disposable equipment; suture material or ...
Process analytical technology (PAT) has been defined by the United States Food and Drug Administration (FDA) as a mechanism to design, analyze, and control pharmaceutical manufacturing processes through the measurement of critical process parameters (CPP) which affect the critical quality attributes (CQA).
Microorganisms growing on an agar plate. Sterilization (British English: sterilisation) refers to any process that removes, kills, or deactivates all forms of life (particularly microorganisms such as fungi, bacteria, spores, and unicellular eukaryotic organisms) and other biological agents (such as prions or viruses) present in fluid or on a specific surface or object. [1]
Halsted's principles, also known as Tenets of Halsted, are the basic principles of surgical technique regarding tissue handling. [1] These key points were introduced in the late 19th century by William Stewart Halsted, co-founder of Johns Hopkins Hospital. [2] [3] Gentle handling of tissue; Meticulous haemostasis; Preservation of blood supply
Aseptic sampling is the process of aseptically withdrawing materials used in biopharmaceutical processes for analysis so as not contaminate or alter the sample or the source of the sample. [1] Aseptic samples are drawn throughout the entire biopharmaceutical process ( cell culture /fermentation, buffer & media prep, purification , final fill ...