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Eumycetoma, also known as Madura foot, [1] [6] is a persistent fungal infection of the skin and the tissues just under the skin, affecting most commonly the feet ...
Most eumycetoma is caused by M. mycetomatis, whereas most actinomycetoma is caused by N. brasiliensis, S. somaliensis, A. madurae, and Actinomadura pelletieri. [1] People who develop mycetoma likely have a weakened immune system. [1] It can take between 3 months to 50 years from the time of infection to first seeking healthcare advice. [1]
In the United States, P. boydii is the most common causal agent of eumycetoma, and tends to be more common in men than in women, particularly in the 20- to 45-year-old age group. [10] In the United States, the incidence of infection by S. apiospermum between 1993 and 1998 was 0.82 per 100,000 patient-inpatient days; this figure increased to 1. ...
Subcutaneous types include eumycetoma and chromoblastomycosis, which generally affect tissues in and beneath the skin. [1] [7] Systemic fungal infections are more serious and include cryptococcosis, histoplasmosis, pneumocystis pneumonia, aspergillosis and mucormycosis. [3] Signs and symptoms range widely. [3]
Mycetoma is a broad term which includes actinomycetoma and eumycetoma under it. However, eumycetoma is caused by fungal infection in contrast to actinomycetoma that is caused by mostly anaerobic bacteria.
Madurella mycetomatis is a main cause of eumycetoma, [2] an infection of human extremities and rarely the nervous system, in arid regions of east Africa and Asia. The origin is soil and its dark agar colonies are often sterile, although sclerotia are often produced, and short chains of 1-celled conidia sometimes occur. [3]
Colonies of Madurella grisea are slow growing, dark, leathery, and folded with radial grooves and with a light brown to greyish surface mycelium. With age, colonies become dark- to reddish-brown and acquire a brownish-black reverse.
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