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An artificial form of RNA consisting entirely of uracil-containing nucleotides (polyuridylic acid or poly-U) was added to the extract, causing it to form a protein composed entirely of the amino acid phenylalanine. This experiment cracked the first codon of the genetic code and showed that RNA controlled the production of specific types of protein.
Nirenberg (right) and Matthaei from 1961 Nirenberg from 1962.. Marshall Warren Nirenberg (April 10, 1927 – January 15, 2010) [1] was an American biochemist and geneticist. [2] He shared a Nobel Prize in Physiology or Medicine in 1968 with Har Gobind Khorana and Robert W. Holley for "breaking the genetic code" and describing how it operates in protein synthesis.
The Nirenberg and Leder experiment was a scientific experiment performed in 1964 by Marshall W. Nirenberg and Philip Leder. The experiment elucidated the triplet nature of the genetic code and allowed the remaining ambiguous codons in the genetic code to be deciphered.
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The Nirenberg and Matthaei experiment, the first to enable recognition and understanding of the genetic code, was performed by Heinrich Matthaei. The date of the Poly-U-Experiment has been described as the birthdate of modern genetics. [72] Marcel Mihalovici's opera Krapp's Last Tape premiered in a French-language version on RTF radio.
This single experiment opened the way to the solution of the genetic code. It was for this and later work on the genetic code for which Nirenberg shared the Nobel Prize for Medicine and Physiology. In addition, Matthaei and his co-workers in the following years published a multitude of results concerning the early understanding of the form and ...
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