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Pyoderma gangrenosum is a rare, inflammatory skin disease where painful pustules or nodules become ulcers that progressively grow. [3] Pyoderma gangrenosum is not infectious. [3] Treatments may include corticosteroids, ciclosporin, infliximab, or canakinumab. [2] The disease was identified in 1930.
The inflammation and ulceration that occurs as a result of pathergy in pyoderma gangrenosum often responds to systemic steroid therapy. The pathergy reaction is a unique feature of Behçet's disease and, according to the International Study Group for Behcet's Disease, is among the major criteria required for the diagnosis.
Pyoderma gangrenosum is variably expressed, which means that it is not always present in all individuals with the disease. It presents as poorly healing ulcers with undermined edges. Pathergy is an important feature (this term refers to the tendency of ulcers to arise at points of injury).
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Pyoderma gangrenosum is a less common skin problem, occurring in under 2%, [69] and is typically a painful ulcerating nodule. [ 68 ] [ 51 ] Clubbing , a deformity of the ends of the fingers, may also be a result of Crohn's disease.
Following biomaterial implantation, blood and body fluids contact the implant surface.Host blood proteins adsorb onto the implant surface and a fibrin matrix forms. [6] Acute and chronic inflammation follow the initial blood protein deposition and matrix formation. [6]
Today's NYT Connections puzzle for Tuesday, February 4, 2025The New York Times
In superficial granulomatous pyoderma, ulcers typically have a clean base and vegetating borders, making them more superficial. Unlike pyoderma gangrenosum, superficial granulomatous pyoderma is more frequently associated with truncal involvement and is not always linked to underlying systemic disease.