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Heat stroke is an acute temperature elevation caused by exposure to excessive heat, or combination of heat and humidity, that overwhelms the heat-regulating mechanisms of the body. The latter is a relatively rare side effect of many drugs, particularly those that affect the central nervous system .
As in other mammals, human thermoregulation is an important aspect of homeostasis. In thermoregulation, body heat is generated mostly in the deep organs, especially the liver, brain, and heart, and in contraction of skeletal muscles. [1] Humans have been able to adapt to a great diversity of climates, including hot humid and hot arid.
Bags of frozen plasma, from a person with hypercholesterolemia (left) and typical plasma (right) Plasma is normally yellow due to bilirubin, carotenoids, hemoglobin, and transferrin. [18] In abnormal cases, plasma can have varying shades of orange, green, or brown. The green color can be due to ceruloplasmin or sulfhemoglobin.
The start of heat stroke can be sudden or gradual. [3] Heatstroke is a life-threatening condition due to the potential for multi-organ dysfunction, [6] with typical complications including seizures, rhabdomyolysis, or kidney failure. [3] Heat stroke occurs because of high external temperatures and/or physical exertion.
Although stress response pathways are mediated in different ways depending on the stressor involved, cell type, etc., a general characteristic of many pathways – especially ones where heat is the principal stressor – is that they are initiated by the presence and detection of denatured proteins. Because conditions such as high temperatures ...
Heat shock proteins (HSPs) are a family of proteins produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock , [ 1 ] but are now known to also be expressed during other stresses including exposure to cold, [ 2 ] UV light [ 3 ] and during wound healing or tissue remodeling. [ 4 ]
Heat illness is a spectrum of disorders due to increased body temperature. It can be caused by either environmental conditions or by exertion.It includes minor conditions such as heat cramps, heat syncope, and heat exhaustion as well as the more severe condition known as heat stroke. [1]
As in other mammals, thermoregulation is an important aspect of human homeostasis. Most body heat is generated in the deep organs, especially the liver, brain, and heart, and in contraction of skeletal muscles. [15] Humans have been able to adapt to a great diversity of climates, including hot humid and hot arid.