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Moxidectin is an anthelmintic drug used in animals to prevent or control parasitic worms , such as heartworm and intestinal worms, in dogs, cats, horses, cattle, sheep and wombats. [4] Moxidectin kills some of the most common internal and external parasites by selectively binding to a parasite's glutamate-gated chloride ion channels.
Mature horses appear to develop a certain degree of resistance to this parasite, but it is a concern for younger horses up to about two years old. [4] P. equorum is one of the few parasites where a natural immunity develops in the host. [3] However, when an infection is found in an adult horse, both the worm and egg counts are substantially low ...
Continuous dewormers are a mild low dose and may be easier on the horse, but may not be effective in quickly killing worms in a heavily-infected horse and may contribute to drug resistance. If a treatment doesn't kill at least 95% of a worm species, that species is classed as 'resistant' to the drug.
Skin lesions probably due to Habronema Horse recovering from skin lesions probably due to Habronema, after treatment with ivermectin. For most horses, the lesions will resolve by the end of summer. Topical or systemic treatment with Ivermectin is effective against Habronemiasis. Ivermectin or moxidectin can eliminate nematodes in the stomach.
pergolide – dopamine receptor agonist used for the treatment of pituitary pars intermedia dysfunction in horses; phenobarbital – anti-convulsant used for seizures; phenylbutazone – nonsteroidal anti-inflammatory drug (NSAID) phenylpropanolamine – controls urinary incontinence in dogs
All major gastrointestinal nematode genera survived treatment in various studies. In cattle, prevalence of anthelminthic resistance varied between anthelmintic classes from 0–100% (benzimidazoles and macrocyclic lactones), 0–17% (levamisole) and 0–73% (moxidectin), and both Cooperia and Ostertagia survived treatment. [14]
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