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The scorpion is perceived both as an embodiment of evil and a protective force such as a dervish's powers to combat evil. [10] In another context, the scorpion portrays human sexuality. [10] Scorpions are used in folk medicine in South Asia, especially in antidotes for scorpion stings. [10]
NTX accounts for only about 1% of the scorpion venom. [7] NTX is one of the best-studied toxic peptides from scorpion venoms. [6] It was the second purified toxin obtained from the genus Centruroides after neurotoxin II [8] and the first short peptide from scorpion venom to be reported in the literature. [9]
Scorpion toxins are proteins found in the venom of scorpions.Their toxic effect may be mammal- or insect-specific and acts by binding with varying degrees of specificity to members of the Voltage-gated ion channel superfamily; specifically, voltage-gated sodium channels, voltage-gated potassium channels, [3] and Transient Receptor Potential (TRP) channels.
The crude venom of T. serrulatus contains different toxins. Some of the strongest derivates are the neurotoxins tityustoxin and toxin Ts-g. [3] Two types of toxins are considered to be responsible for the main toxic effect: toxin gamma (a β-type toxin) and tityustoxin (TsTX, an α-type toxin), both with a specific affinity to the sodium channel. [4]
The deathstalker is one of the most dangerous species of scorpions. [10] [11] Its venom is a powerful mixture of neurotoxins, with a low lethal dose. [12]While a sting from this scorpion is extraordinarily painful, it normally would not kill a healthy adult human.
Tb1 is a sodium channel scorpion toxin (NaScTx) and belongs to the beta toxin subfamily. [2] Within the NaScTx family, Tb1 is part of the NaTx6 cluster. This cluster consists of four toxins found in the venom of scorpions that inhabit the Southern area of the Amazonian rainforest: Tco-gamma, Tst1, Tb1 and the previously mentioned Ts1. [6]
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Tityus serrulatus, the Brazilian yellow scorpion, is a species of scorpion of the family Buthidae. It is native to Brazil , and its venom is extremely toxic. [ 1 ] It is the most dangerous scorpion in South America and is responsible for the most fatal cases.