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[5] [9] The use of plasmapheresis in those with GPA and acute kidney failure (renal vasculitis) might reduce progression to end-stage kidney disease at three months. [9] Oral and intravenous cyclophosphamide are both effective for induction of GPA remission.
Cyclophosphamide is also used to treat minimal change disease, [8] severe rheumatoid arthritis, granulomatosis with polyangiitis, [5] Goodpasture syndrome [9] and multiple sclerosis. [ 10 ] Because of its potential side effects such as amenorrhea or ovarian failure , cyclophosphamide is used for early phases of treatment and later substituted ...
Variable vessel vasculitis (VVV) is a kind of vasculitis that may impact vessels of all sizes (small, medium, and large) and any type (arteries, veins, and capillaries), with no particular type of vessel being predominantly affected. [33] This category includes Behcet's disease (BD) and Cogan's syndrome (CS). [8]
Drug side effects, such as NSAIDs (non-steroidal anti-inflammatories), cyclophosphamide, cyclosporine and tacrolimus. Small vessel vascular disease results in renal vasculitis, whereas large vessel involvement causes aneurysms (bulging) and thrombosis (blockages). Serious kidney problems are more common in men typically with a history of large ...
Mouth and genital ulcers with inflamed cartilage syndrome or MAGIC syndrome is a condition in which an individual exhibits symptoms of both relapsing polychondritis (RP) and Behcet's disease (BD). [1] Inflammatory ulcers in the mouth, genitalia, and skin are the hallmark of Behcet's disease (BD), a multisystem illness that is chronic and ...
The disease spectrum varies from failure of multiple organs to involvement of a single organ. Almost any organ could be impacted; however, polyarteritis nodosa rarely affects the lungs for unknown reasons. [10] Kawasaki disease is a type of systemic vasculitis of medium-sized vessels with an acute onset that primarily affects young children.
Type III RPGN may be isolated to the glomerulus (primary, or idiopathic) or associated with a systemic disease (secondary). In most cases of the latter, the systemic disease is an ANCA-associated vasculitis such as granulomatosis with polyangiitis, microscopic polyangiitis or eosinophilic granulomatosis with polyangiitis. [2]
Possible secondary causes of cerebral vasculitis are infections such as with varicella zoster virus (chicken pox or shingles), systemic auto-immune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, medications and drugs (amphetamine, cocaine and heroin), some forms of cancer (lymphomas, leukemia and lung cancer) and ...