Search results
Results From The WOW.Com Content Network
The studies demonstrating that U=U is an effective strategy for preventing HIV transmission in serodiscordant couples so long as "the partner living with HIV [has] a durably suppressed viral load" include: [88] Opposites Attract, [89] PARTNER 1, [43] PARTNER 2, [90] [91] (for male–male couples) [88] and HPTN052 [92] (for heterosexual couples ...
Sero-discordant couples were used in the study and each couple was provided either early or delayed antiretroviral treatment. Over a five-year period, researchers concluded that early ART was cost-saving in South Africa and cost-effective in India. Over a lifetime, early ART was determined to be very cost-effective in both countries.
There are two major mechanisms of NRTI resistance. The first being reduced incorporation of the nucleotide analog into DNA over the normal nucleotide. This results from mutations in the N-terminal polymerase domain of the reverse transcriptase that reduce the enzyme's affinity or ability to bind to the drug .
Common side effects include headaches, fever, and nausea. [6] Serious side effects include liver problems, muscle damage, and high blood lactate levels. [6] It is commonly used in pregnancy and appears to be safe for the fetus. [6] ZDV is of the nucleoside analog reverse-transcriptase inhibitor (NRTI) class. [6]
Using male or female condom during sex, [5] being tested for HIV and sexually transmitted infections, [5] having a voluntary medical male circumcision, [5] using harm reduction services for people who inject and use drugs, [5] antiretroviral drugs (ARVs) (including oral Pre-exposure prophylaxis (PrEP) and long acting products, [5] dapivirine ...
There is no data available for stavudine use in HIV-infected adults aged 65 years or older. However, among 12,000 people over the age of 65, 30% developed peripheral neuropathy. [2] Additionally, since the elderly are more likely to have decreased renal function, they are more likely to develop toxic side effects. [11]
Neuropsychiatric effects are the most common adverse effects, and include disturbed sleep (including nightmares, insomnia, disrupted sleep, and daytime fatigue), dizziness, headaches, vertigo, blurred vision, anxiety, and cognitive impairment (including fatigue, confusion, and memory and concentration problems), and depression, including suicidal thinking.
It is taken by mouth as a tablet or solution and may be used in children over the age of three months. [5] [8] Abacavir is generally well tolerated. [8] Common side effects include vomiting, insomnia (trouble sleeping), fever, and feeling tired. [5]