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In pharmacology, clearance is a pharmacokinetic parameter representing the efficiency of drug elimination. This is the rate of elimination of a substance divided by its concentration. [ 1 ] The parameter also indicates the theoretical volume of plasma from which a substance would be completely removed per unit time.
Security clearances can be issued by many United States of America government agencies, including the Department of Defense (DoD), the Department of State (DOS), the Department of Homeland Security (DHS), the Department of Energy (DoE), the Department of Justice (DoJ), the National Security Agency (NSA), and the Central Intelligence Agency (CIA).
Clearance is therefore expressed as the plasma volume totally free of the drug per unit of time, and it is measured in units of volume per units of time. Clearance can be determined on an overall, organism level («systemic clearance») or at an organ level (hepatic clearance, renal clearance etc.). The equation that describes this concept is:
An interim clearance may be denied (although the final clearance may still be granted) for having a large amount of debt, [40] having a foreign spouse, for having admitted to seeing a doctor for a mental health condition, or for having admitted to other items of security concern (such as a criminal record or a history of drug use.). When ...
In pharmacology, augmented renal clearance (ARC) is a phenomenon where certain critically ill patients may display increased clearance of a medication through the kidneys. In many cases, it is observed as a measured creatinine clearance above that which is expected given the patient's age, gender, and other factors.
In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body.
The term clearance has a general and a specific meaning. In general, clearance refers to the removal of substances from the body. But in renal physiology, clearance specifically refers to the volume of plasma per unit time that is cleared of a particular substance. You're right that it is a rate, but that's just assumed when you say renal ...
The government may wish to limit certain types of sensitive information only to those who work directly on related programs, regardless of the collateral clearance they hold. Thus, even someone with a Top Secret clearance cannot gain access to its Confidential information unless it is specifically granted.