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It was established in 2000, as an expansion of the Nature family of journals. The editor-in-chief is Jamie D. K. Wilson. [1] According to the Journal Citation Reports, the journal has a 2021 impact factor of 31.250, ranking it 4th out of 161 journals in the category "Immunology". [2]
The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. [5] It is a 13kbp gene on chromosome 21q22.3 that encodes 545 amino acids. [6] AIRE is a transcription factor expressed in the medulla [broken anchor] (inner part) of the thymus.
The Nature Partner Journals series, abbreviated npj, is a series of online-only, open access, journals. It was launched in April 2014 with three journals: npj Primary Care Respiratory Medicine , npj Biofilms and Microbiomes , and npj Schizophrenia .
Nature Reviews Immunology is a monthly review journal covering the field of immunology. [1] The journal also publishes "Research highlight" articles, which are short summaries written by the editors that describe recent hot research papers. The editor-in-chief is Alexandra Flemming. [2]
Lymphocytes generate the immune repertoire by recombining the genes encoding immunoglobulins and T cell receptors through V(D)J recombination.Although there are only a few of these genes, all their possible combinations can result in a wide variety of immune repertoire proteins.
340061 72512 Ensembl ENSG00000184584 ENSG00000288243 ENSMUSG00000024349 UniProt Q86WV6 Q3TBT3 RefSeq (mRNA) NM_001301738 NM_198282 NM_001367258 NM_001289591 NM_001289592 NM_028261 RefSeq (protein) NP_001288667 NP_938023 NP_001354187 NP_001276520 NP_001276521 NP_082537 Location (UCSC) Chr 5: 139.48 – 139.48 Mb Chr 18: 35.87 – 35.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ...
Cancer Therapy by Inhibition of Negative Immune Regulation (CTLA4, PD1) A2AR & A2BR: The Adenosine A2A receptor is regarded as an important checkpoint in cancer therapy because adenosine in the immune microenvironment, leading to the activation of the A2a receptor, is negative immune feedback loop and the tumor microenvironment has relatively high concentrations of adenosine. [27]
29851 54167 Ensembl ENSG00000163600 ENSMUSG00000026009 UniProt Q9Y6W8 Q9WVS0 RefSeq (mRNA) NM_012092 NM_017480 RefSeq (protein) NP_036224 NP_059508 Location (UCSC) Chr 2: 203.94 – 203.96 Mb Chr 1: 61.02 – 61.04 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Inducible T-cell costimulator (also called CD278) is an immune checkpoint protein that in humans is encoded by the ICOS (I ...