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Cochlear hydrops (or cochlear Meniere's or cochlear endolymphatic hydrops) is a condition of the inner ear involving a pathological increase of fluid affecting the cochlea. This results in swelling that can lead to hearing loss or changes in hearing perception. It is a form of endolymphatic hydrops and related to Ménière's disease. Cochlear ...
Endolymphatic hydrops is a disorder of the inner ear. It consists of an excessive build-up of the endolymph fluid, which fills the hearing and balance structures of the inner ear. Endolymph fluid, which is partly regulated by the endolymph sac, flows through the inner ear and is critical to the function of all sensory cells in the inner ear.
Hearing: Cochlear duct: fluid waves in the endolymph of the cochlear duct stimulate the receptor cells, which in turn translate their movement into nerve impulses that the brain perceives as sound. Balance: Semicircular canals: angular acceleration of the endolymph in the semicircular canals stimulate the vestibular receptors of the endolymph.
[36] [37] However, recent pharmacokinetic experiments have shown that combination therapy with Monoamine oxidase inhibitors can drastically increase the bioavailability of betahistine in humans, [38] and improve cochlear blood flow in guinea pigs. [39] Transtympanic micropressure pulses were investigated in two systematic reviews.
A resting endolymphatic potential of a normal cochlea is + 80 mV. There are at least 3 other potentials generated upon cochlear stimulation: Cochlear microphonic (CM) Summating potential (SP) Action potential (AP) As described above, the cochlear microphonic (CM) is an alternating current (AC) voltage that mirrors the waveform of the acoustic ...
Structural diagram of the cochlea showing how fluid pushed in at the oval window moves, deflects the cochlear partition, and bulges back out at the round window. The cochlea ( pl. : cochleae) is a spiraled, hollow, conical chamber of bone, in which waves propagate from the base (near the middle ear and the oval window ) to the apex (the top or ...
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Perilymph is the fluid contained within the bony labyrinth, surrounding and protecting the membranous labyrinth; perilymph resembles extracellular fluid in composition (sodium salts are the predominant positive electrolyte) and, via the cochlear aqueduct (sometimes referred to as the "perilymphatic duct"), is in continuity with cerebrospinal fluid.
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