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Cyanide poisoning inhibits aerobic respiration and therefore increases anaerobic glycolysis which causes a rise of lactate in the plasma. A lactate concentration above 10 mmol per liter is an indicator of cyanide poisoning, as defined by the presence of a blood cyanide concentration above 40 μmol per liter.
4-Dimethylaminophenol has been used as an antidote for cyanide poisoning. [1] It has also been shown to be effective in treating hydrogen sulfide toxicity. [2] It works by generating methemoglobin. [3] This is suitable as an emergency treatment only; treatment must be followed up with sodium thiosulfate or cobalamin.
Amyl nitrite was historically employed medically to treat heart diseases as well as angina.; Amyl nitrite was sometimes used as an antidote for cyanide poisoning. [6] [7] It was thought to act as an oxidant, to induce the formation of methemoglobin.
Sodium thiosulfate is a classical antidote to cyanide poisoning, [10] For this purpose it is used after the medication sodium nitrite and typically only recommended for severe cases. [4] [6] It is given by injection into a vein. [4] In this use, sodium nitrite creates methemoglobinemia which removes cyanide from mitochondria. [6]
“This antidote will limit damage from gas poisoning caused by sudden fires and can be tested for the treatment of various symptoms caused by gas poisoning,” study co-author Hiroaki Kitagishi ...
Sulfanegen is an experimental antidote for cyanide poisoning. [1] It is being studied as a prodrug for 3-mercaptopyruvic acid (3-MP). 3-MP has been studied as a potential treatment for cyanide poisoning, but the half-life is too short for it to be clinically effective. [2]
A Thai woman believed to be among the worst serial killers in the kingdom's history was convicted and sentenced to death Wednesday for poisoning a friend with cyanide, in the first of her 14 ...
Heavy metal poisoning: Cyanide antidotes (hydroxocobalamin, amyl nitrite, sodium nitrite, or thiosulfate) Cyanide poisoning: Cyproheptadine: Serotonin syndrome: Deferoxamine mesylate Iron poisoning: Digoxin Immune Fab antibody (Digibind and Digifab) Digoxin poisoning, Oleander ingestion [8] Diphenhydramine hydrochloride and benztropine mesylate