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Overactive bladder (OAB) is a common condition where there is a frequent feeling of needing to urinate to a degree that it negatively affects a person's life. [2] The frequent need to urinate may occur during the day, at night , or both. [ 4 ]
What is overactive bladder? Overactive bladder isn’t a disease but rather a syndrome defined by a collection of symptoms, says Jennifer Linehan, MD, a urologist and associate professor of ...
The chemical structure of Solabegron, a β 3-adrenergic receptor agonist. Mirabegron is a selective β 3-AR agonist that affects the detrusor muscles of the urinary bladder.By stimulation of β 3-AR the contraction of the smooth muscles of the bladder is decreased and the bladder can store more volume of urine at a given time.
Urination, or voiding, is a complex activity. The bladder is a balloon-like muscle that lies in the lowest part of the abdomen. The bladder stores urine and then releases it through the urethra, which is the canal that carries urine to the outside of the body. Controlling this activity involves nerves, muscles, the spinal cord and the brain.
Diagnosis involves ruling out other potential causes of the symptoms such as bacterial prostatitis, benign prostatic hyperplasia, overactive bladder, and cancer. [ 2 ] [ 5 ] Recommended treatments include multimodal therapy , physiotherapy , and a trial of alpha blocker medication or antibiotics in certain newly diagnosed cases. [ 6 ]
Mirabegron, sold under the brand name Myrbetriq among others, is a medication used to treat overactive bladder. [5] Its benefits are similar to antimuscarinic medication such as solifenacin or tolterodine. [6] It is taken by mouth. [5] Common side effects include high blood pressure, headaches, and urinary tract infections. [5]