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Anonychia is the failure to form fingernails or toenails. [ 1 ] It is an anomaly which may be the result of a congenital ectodermal defect, ichthyosis , severe infection, severe allergic contact dermatitis , self-inflicted trauma , Raynaud phenomenon , lichen planus , epidermolysis bullosa , or severe exfoliative diseases.
The lack of development or complete absence of fingernails results from the loss of function mutations in the LMX1B gene. This mutation may cause a reduction in dorsalising signals, which then results in the failure to normally develop dorsal specific structures such as nails and patellae. [10]
Cooks syndrome is a hereditary disorder which is characterized in the hands by bilateral nail hypoplasia on the thumb, index finger, and middle finger, absence of fingernails on the ring finger and little finger, lengthening of the thumbs, and bulbousness of the fingers.
Nail clubbing - nails that curve down around the fingertips with nailbeds that bulge is associated with oxygen deprivation and lung, heart, or liver disease. Koilonychia - spooning, or nails that grow upwards. Associated with iron-deficiency anaemia or vitamin B 12 deficiency. [citation needed] Pitting of the nails is associated with psoriasis.
The finger and toenails are characteristically small, with complete or almost complete absence of the nails of the thumb (pollex) and great toe (hallux). [4] [5] The diagnosis can be confirmed by demonstrating a gain-of-function mutation in the KCNH1 gene. [6] Temple–Baraitser has clinical and genetic overlap with type 1 Zimmermann–Laband ...
Pachyonychia congenita is a rare disorder with an unknown prevalence. As of 2018, the International PC Research Registry has identified approximately 774 individuals with the disease, but prevalence is estimated to be 5,000–10,000 worldwide. [1] [7] The disease affects both males and females.
3. Depending on your nail strength, acrylics may cause a splitting or painful nail plate. Pay close attention to how strong and think your nails are. Extremely thin nails may not be the best for ...
Bart syndrome, also known as aplasia cutis congenita type VI, is a rare genetic disorder characterized by the association of congenital localized absence of skin, mucocutaneous blistering and absent and dystrophic nails. [1] [2]